European Respiratory Review

Meeting unmet needs in asthma:
the leukotriene receptor antagonists

Edited by S. Holgate

CONTENTS

S. Holgate	1027	Foreword
S. Holgate	1028	The history of drug development and asthma management
K.F. Chung	1033	Unmet clinical needs in asthma: childhood to old age
A.P. Sampson	1037	The pharmacology of leukotriene receptor antagonists
J.C. Virchow Jr	1042	Clinical efficacy of the leukotriene receptor antagonists in mild, moderate and severe asthma
B. Björksén	1046	Meeting the needs of special patient groups: the contribution of leukotriene receptor antagonist therapy in paediatric and adolescent asthma
L. Dow	1048	Meeting the needs of special patient groups: the contribution of leukotriene receptor antagonist therapy for asthma in the elderly
R.D. Mann	1051	Adverse reactions and the science of pharmacosurveillance
N. Barnes	1054	Replacing or reducing high-dose oral corticosteroids with alternative asthma controller therapies: implications for leukotriene receptor antagonists
B. Hart	1056	Replacing or reducing high-dose oral corticosteroids with alternative asthma controller therapies: implications for leukotriene receptor antagonists
J.P. Kemp	1059	The place of leukotriene receptor antagonists in addressing unmet needs, including practical guidance for prescribing physicians
S. Holgate	1063	Concluding remarks

Manuscripts